A partner was struggling with the glycosylation profile of their mAbs. Some glycoforms were present at too low a level, others at too high a level.
Case Studies
Improved the glycosylation profile of a partner's mAbs.
Systematically vary media composition
Insilico ran thousands of metabolic simulations, systematically varying media composition, in pursuit of a more desirable glycosylation profile.
The result: experimentally validated
91%
G1F increase
63%
G2F increase
12%
G0 decrease
63%
G0F-N decrease
61%
Man5 decrease
Want to improve your product's glycosylation profile?